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Article

High mutation rate and predominance of insertions in the Caenorhabditis elegans nuclear genome.

Nature - 5 Aug 2004

Denver Dee R, Morris Krystalynne, Lynch Michael, Thomas W Kelley

Abstract excerpt

Mutations have pivotal functions in the onset of genetic diseases and are the fundamental substrate for evolution. However, present estimates of the spontaneous mutation rate and spectrum are derived from indirect and biased measurements. For instance, mutation rate estimates for Caenorhabditis elegans are extrapolated from observations on a few genetic loci with visible phenotypes and vary over an order of...

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PMID: 15295601
DOI: 10.1038/nature02697

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