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Article

Variation in base-substitution mutation in experimental and natural lineages of Caenorhabditis nematodes.

Genome biology and evolution - 1 Jan 2012

Denver Dee R, Wilhelm Larry J, Howe Dana K, Gafner Kristin, Dolan Peter C, Baer Charles F

Abstract excerpt

Variation among lineages in the mutation process has the potential to impact diverse biological processes ranging from susceptibilities to genetic disease to the mode and tempo of molecular evolution. The combination of high-throughput DNA sequencing (HTS) with mutation-accumulation (MA) experiments has provided a powerful approach to genome-wide mutation analysis, though insights into mutational variation have...

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Identifiers

PMID: 22436997
DOI: 10.1093/gbe/evs028
PMCID: PMC3342874

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