Article
A genome-wide view of Caenorhabditis elegans base-substitution mutation processes.
Proceedings of the National Academy of Sciences of the United States of America - 22 Sept 2009
Denver Dee R, Dolan Peter C, Wilhelm Larry J, Sung Way, Lucas-Lledó J Ignacio, Howe Dana K, Lewis Samantha C, Okamoto Kazu, Thomas W Kelley, Lynch Michael, Baer Charles F
Abstract excerpt
Knowledge of mutation processes is central to understanding virtually all evolutionary phenomena and the underlying nature of genetic disorders and cancers. However, the limitations of standard molecular mutation detection methods have historically precluded a genome-wide understanding of mutation rates and spectra in the nuclear genomes of multicellular organisms. We applied two high-throughput DNA sequencing...
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