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Article

Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Oct 2000

Lomaga M A, Henderson J T, Elia A J, Robertson J, Noyce R S, Yeh W C, Mak T W

Abstract excerpt

Tumor necrosis factor receptor-associated factors (TRAFs) are adaptor proteins important in mediating intracellular signaling. We report here that targeted deletion of traf6 greatly increases the frequency of failure of neural tube closure and exencephaly in traf6 (-/-) mice. The penetrance of this defect is influenced by genetic background. Neural tube fusion requires the coordination of several biological...

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Identifiers

PMID: 11007897
PMCID: PMC6772765

Genes

TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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