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Article

Neurotrophin receptor-mediated death of misspecified neurons generated from embryonic stem cells lacking Pax6.

Cell stem cell - 1 Nov 2007

Nikoletopoulou Vassiliki, Plachta Nicolas, Allen Nicolas D, Pinto Luisa, Götz Magdalena, Barde Yves-Alain

Abstract excerpt

Pax6-positive radial glial (RG) cells are the progenitors of most glutamatergic neurons in the cortex, a lineage that can be recapitulated in vitro using embryonic stem (ES) cells. We show here that ES cells lacking Pax6, a transcription factor long known to be essential for cortical development, generate Mash1-positive RG cells that differentiate in GABAergic neurons. These neurons express high levels of the...

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PMID: 18371392
DOI: 10.1016/j.stem.2007.08.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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