Article
Neurotrophin receptor-mediated death of misspecified neurons generated from embryonic stem cells lacking Pax6.
Cell stem cell - 1 Nov 2007
Nikoletopoulou Vassiliki, Plachta Nicolas, Allen Nicolas D, Pinto Luisa, Götz Magdalena, Barde Yves-Alain
Abstract excerpt
Pax6-positive radial glial (RG) cells are the progenitors of most glutamatergic neurons in the cortex, a lineage that can be recapitulated in vitro using embryonic stem (ES) cells. We show here that ES cells lacking Pax6, a transcription factor long known to be essential for cortical development, generate Mash1-positive RG cells that differentiate in GABAergic neurons. These neurons express high levels of the...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Cell Death
- Cell Differentiation
- Cell Line
- Cell Lineage
- Cerebral Cortex
- Chick Embryo
- Embryonic Stem Cells
- Eye Proteins
- Gestational Age
- Glutamic Acid
- Homeodomain Proteins