Microsatellite instability in germ cell tumors of the testis and ovary.

doi:10.1006/gyno.2000.5906

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Article

Microsatellite instability in germ cell tumors of the testis and ovary.

Gynecologic oncology - 1 Oct 2000

Faulkner S W, Friedlander M L

Abstract excerpt

OBJECTIVES: Widespread replication-type error (RER) is a genetic alteration that has been observed in many different neoplasms and has been associated with defective DNA repair activity. There are conflicting data regarding the role that this type of genetic instability plays in the development and progression of adult germ cell tumors. METHODS: Universal amplification was performed on 104 paired specimens of...

Topics

Adolescent
Adult
Alleles
Carcinoma in Situ
DNA Repair
DNA Replication
DNA, Neoplasm
Female
Germinoma
Humans
Male
Microsatellite Repeats
Ovarian Neoplasms
Polymerase Chain Reaction
Testicular Neoplasms

Source

Open in PubMed

Identifiers

PMID: 11006028
DOI: 10.1006/gyno.2000.5906

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