Article
Allelic deletions in the long arm of chromosome 12 identify sites of candidate tumor suppressor genes in male germ cell tumors.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 1992
Murty V V, Houldsworth J, Baldwin S, Reuter V, Hunziker W, Besmer P, Bosl G, Chaganti R S
Abstract excerpt
Human male germ cell tumors (GCTs) result from malignant transformation of premeiotic or early meiotic germ cells and exhibit embryonal-like differentiation of the three germinal layers. The genetic basis of origin and expression of differentiated phenotypes by GCTs are poorly understood. Our recent cytogenetic analysis of a large series of GCTs has shown that two chromosome 12 abnormalities, an isochromosome for...
Topics
- Alleles
- Blotting, Northern
- Blotting, Southern
- Cell Transformation, Neoplastic
- Chromosome Banding
- Chromosomes, Human, Pair 12
- DNA
- DNA Probes
- DNA, Neoplasm
- Gene Deletion