Article
Absence of microsatellite instability and BRAF (V600E) mutation in testicular germ cell tumors.
Andrology - 1 Sept 2016
Cárcano F M, Lengert A H, Vidal D O, Scapulatempo Neto C, Queiroz L, Marques H, Baltazar F, Berardinelli G N, Martinelli C M S, da Silva E C A, Reis R M, Lopes L F
Abstract excerpt
Testicular germ cell tumors (TGCT) are the most common malignant neoplasm in young men. DNA mismatch repair deficiency can lead to microsatellite instability (MSI), an important mechanism of genetic instability. A mutation of the BRAF gene has been implicated in the pathogenesis of several solid tumors and has recently become an important therapeutic target. The role of MSI and BRAF gene mutation in TGCT,...
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