Replication error-type genetic instability at 1q42-43 in human male germ cell tumors.

Article

Replication error-type genetic instability at 1q42-43 in human male germ cell tumors.

Cancer research - 1 Aug 1994

Murty V V, Li R G, Mathew S, Reuter V E, Bronson D L, Bosl G J, Chaganti R S

Abstract excerpt

The replication error phenotype, recognized as microsatellite sequence alterations, has recently been suggested to be associated with hereditary nonpolyposis colorectal cancer and other types of sporadic tumors. We examined paired tumor-normal DNAs from 69 human male germ cell tumors for somatic...

Topics

Chromosomes, Human, Pair 1
DNA Replication
DNA, Satellite
Gene Deletion
Gene Rearrangement
Germinoma
Humans
In Situ Hybridization
Male
Phenotype
Tumor Cells, Cultured

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