Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Conservation of Regulatory Elements in the pdx-1 Gene: PDX-1 and Hepatocyte Nuclear Factor 3β Transcription Factors Mediate β-Cell-Specific Expression

15 Oct 2000

Abstract excerpt

The PDX-1 transcription factor plays a key role in pancreatic development and in the regulation of the insulin gene in the adult beta cell. As its functions appear to be similar in humans and mice, we analyzed the functional conservation of homologous sequences important for the maintenance and the cell-specific regulation of the pdx-1 gene. Apart from the proximal promoter region, three highly homologous (PH1 to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Genetics and Neurodevelopmental Disorders
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11003654
DOI: 10.1128/mcb.20.20.7583-7590.2000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Conservation of Regulatory Elements in the pdx-1 Gene: PDX-1 and Hepatocyte Nuclear Factor 3β Transcription Factors Mediate β-Cell-Specific ExpressionPMID 11003654Read ↗

A Pancreatic β-Cell-specific Enhancer in the HumanPDX-1 Gene Is Regulated by Hepatocyte Nuclear Factor 3β (HNF-3β), HNF-1α, and SPs Transcription FactorsSemantic proximity Read ↗

Conserved Transcriptional Regulatory Domains of the pdx-1 GeneSemantic proximity Read ↗

Regulation of pdx-1 Gene ExpressionSemantic proximity Read ↗

Pancreatic β Cell-specific Transcription of thepdx-1 GeneSemantic proximity Read ↗

Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6.Semantic proximity Read ↗

Involvement of PDX-1 in activation of human insulin gene transcriptionSemantic proximity Read ↗

Transcription Factors in Islet Development and Physiology: Role of PDX‐1 in Beta‐Cell FunctionSemantic proximity Read ↗

Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1.Semantic proximity Read ↗

Functional expression and analysis of the pancreatic transcription factor PDX-1 in yeast.Semantic proximity Read ↗

Involvement of the Homeodomain-Containing Transcription Factor PDX-1 in Islet Amyloid Polypeptide Gene TranscriptionSemantic proximity Read ↗

Pancreatic duodenal homeobox factor-1and diabetes mellitus type 2 (Review)Semantic proximity Read ↗

PDX1 directs a core developmentally and evolutionarily conserved gene program in the pancreatic isletSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.