Article
Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1.
Developmental biology - 1 Oct 2001
Gannon M, Gamer L W, Wright C V
Abstract excerpt
pdx1 (pancreatic and duodenal homeobox gene-1), which is expressed broadly in the embryonic pancreas and, later, in a more restricted manner in the mature beta cells in the islets of Langerhans, is essential both for organ formation and beta cell gene expression and function. We carried out a transgenic reporter gene analysis to identify region- and cell type-specific regulatory regions in pdx1. A 14.5-kb pdx1...
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