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Article

Pancreatic duodenal homeobox factor-1and diabetes mellitus type 2 (Review)

1 Apr 2008

Abstract excerpt

The homeobox domain transcription factor PDX-1 is essential for pancreatic development and for the maintenance of beta-cell function. The participation of pancreatic duodenal homeobox factor-1 (PDX-1) in the transcription of several genes which are essential for glucose sensing and insulin synthesis underlines its key role in beta-cells of the pancreas. PDX-1 binds to the promoter of insulin, glucose transporter...

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Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18360684
DOI: 10.3892/ijmm.21.4.399

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Related research

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Pancreatic duodenal homeobox factor-1and diabetes mellitus type 2 (Review)PMID 18360684Read ↗

Epigenetic Regulation of PDX-1 in Type 2 Diabetes MellitusSemantic proximity Read ↗

Pancreatic Duodenal Homeobox (PDX-1) in health and disease.Semantic proximity Read ↗

Transcription Factors in Islet Development and Physiology: Role of PDX‐1 in Beta‐Cell FunctionSemantic proximity Read ↗

Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function.Semantic proximity Read ↗

Pdx1 and other factors that regulate pancreatic β‐cell survivalSemantic proximity Read ↗

Crucial Role of PDX-1 in Pancreas Development, β-Cell Differentiation, and Induction of Surrogate β-CellsSemantic proximity Read ↗

Biophysical insights into glucose-dependent transcriptional regulation by PDX1Semantic proximity Read ↗

PDX1 directs a core developmentally and evolutionarily conserved gene program in the pancreatic isletSemantic proximity Read ↗

Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300.Semantic proximity Read ↗

PDX1 is the cornerstone of pancreatic β-cell functions and identitySemantic proximity Read ↗

Research Resource: The Pdx1 Cistrome of Pancreatic IsletsSemantic proximity Read ↗

Conserved Transcriptional Regulatory Domains of the pdx-1 GeneSemantic proximity Read ↗

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