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Article

Myocardin-dependent Activation of the CArG Box-rich Smooth Muscle γ-Actin Gene

22 Sept 2009

Abstract excerpt

Serum response factor (SRF) is a ubiquitously expressed transcription factor that binds a 10-bp element known as the CArG box, located in the proximal regulatory region of hundreds of target genes. SRF activates target genes in a cell- and context-dependent manner by assembling unique combinations of cofactors over CArG elements. One particularly strong SRF cofactor, myocardin (MYOCD), acts as a component of a...

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PMID: 19797053
DOI: 10.1074/jbc.m109.033910

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