Article
Identification of direct serum-response factor gene targets during Me2SO-induced P19 cardiac cell differentiation.
The Journal of biological chemistry - 13 May 2005
Zhang Shu Xing, Garcia-Gras Eduardo, Wycuff Diane R, Marriot Suzanne J, Kadeer Nijiati, Yu Wei, Olson Eric N, Garry Daniel J, Parmacek Michael S, Schwartz Robert J
Abstract excerpt
Serum-response factor (SRF) is an obligatory transcription factor, required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Protein A-TEV-tagged chromatin immunoprecipitation technology was used to collect direct SRF-bound gene targets from pluripotent P19 cells, induced by Me2SO treatment into an enriched cardiac cell population. From 242 sequenced DNA fragments, we...
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