Activation of skeletal alpha-actin gene transcription: the cooperative formation of serum response factor-binding complexes over positive cis-acting promoter serum response elements displaces a negative-acting nuclear factor enriched in replicating myoblasts and nonmyogenic cells.

doi:10.1128/mcb.11.10.5090-5100.1991

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Article

Activation of skeletal alpha-actin gene transcription: the cooperative formation of serum response factor-binding complexes over positive cis-acting promoter serum response elements displaces a negative-acting nuclear factor enriched in replicating myoblasts and nonmyogenic cells.

Molecular and cellular biology - 1 Oct 1991

Lee T C, Chow K L, Fang P, Schwartz R J

Abstract excerpt

Three upstream CBAR cis-acting promoter elements, containing the inner core CC(A/T)6GG of the serum response element (SRE), are required for myogenic cell type-restricted expression of the avian skeletal alpha-actin gene (K.L. Chow and R.J. Schwartz, Mol. Cell. Biol. 10:528-538, 1990). These actin SRE elements display differential binding properties with two distinct nuclear proteins, serum response factor (SRF)...

Topics

Actins
Animals
Base Sequence
Cells, Cultured
Chick Embryo
DNA-Binding Proteins
Escherichia coli
Gene Expression Regulation
Molecular Sequence Data
Muscles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Oligonucleotides

Promoter Regions, Genetic

Repressor Proteins

Serum Response Factor

Source

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Identifiers

PMID: 1922033
DOI: 10.1128/mcb.11.10.5090-5100.1991
PMCID: PMC361518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1922033-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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