MAP kinase activation is essential for oncogenic transformation of NIH3T3 cells by Mos.

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Article

MAP kinase activation is essential for oncogenic transformation of NIH3T3 cells by Mos.

Oncogene - 16 Mar 1995

Okazaki K, Sagata N

Abstract excerpt

The c-mos proto-oncogene product, Mos, is a serine/threonine protein kinase that controls the meiotic cell cycle in vertebrate oocytes. Both in vivo and in vitro, Mos can activate mitogen-activated protein kinase (MAPK) most probably by direct phosphorylation of MAPK kinase (MAPKK). In many cell...

Topics

3T3 Cells
Amino Acid Sequence
Animals
Cell Transformation, Neoplastic
Enzyme Activation
MAP Kinase Kinase 1
Mice
Mitogen-Activated Protein Kinase Kinases
Molecular Sequence Data
Phenotype
Protein Serine-Threonine Kinases
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mos
Proto-Oncogene Proteins c-raf
ras Proteins

Source

Open in PubMed

Identifiers

PMID: 7700641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7700641-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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