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Article

MAP kinase activation is essential for oncogenic transformation of NIH3T3 cells by Mos.

Oncogene - 16 Mar 1995

Okazaki K, Sagata N

Abstract excerpt

The c-mos proto-oncogene product, Mos, is a serine/threonine protein kinase that controls the meiotic cell cycle in vertebrate oocytes. Both in vivo and in vitro, Mos can activate mitogen-activated protein kinase (MAPK) most probably by direct phosphorylation of MAPK kinase (MAPKK). In many cell types transformed by diverse oncogene products such as Raf, MAPK is constitutively activated, suggesting that the MAPK...

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PMID: 7700641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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MAP kinase activation is essential for oncogenic transformation of NIH3T3 cells by Mos.PMID 7700641Read ↗

Constitutively active mitogen-activated protein kinase kinase 1 (MAPKK1) and MAPKK2 mediate similar transcriptional and morphological responses.Semantic proximity Read ↗

The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.Semantic proximity Read ↗

What does mos do in oocytes and somatic cells?Semantic proximity Read ↗

Mos activates MAP kinase in mouse oocytes through two opposite pathways.Semantic proximity Read ↗

The JNK/SAPK activator mixed lineage kinase 3 (MLK3) transforms NIH 3T3 cells in a MEK-dependent fashion.Semantic proximity Read ↗

Transformation of mammalian cells by constitutively active MAP kinase kinase.Semantic proximity Read ↗

Transfection of constitutively active mitogen-activated protein/extracellular signal-regulated kinase kinase confers tumorigenic and metastatic potentials to NIH3T3 cells.Semantic proximity Read ↗

Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts.Semantic proximity Read ↗

Interference with the constitutive activation of ERK1 and ERK2 impairs EWS/FLI-1-dependent transformation.Semantic proximity Read ↗

Transformation by Raf and other oncogenes renders cells differentially sensitive to growth inhibition by a dominant negative c-jun mutant.Semantic proximity Read ↗

A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation.Semantic proximity Read ↗

MEK kinase 1 is essential for Bcr-Abl-induced STAT3 and self-renewal activity in embryonic stem cells.Semantic proximity Read ↗

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