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Article

Identification of an enhancer and an alternative promoter in the first intron of the alpha-fetoprotein gene.

Nucleic acids research - 1 Oct 2000

Scohy S, Gabant P, Szpirer C, Szpirer J

Abstract excerpt

In this study we have characterized a positive regulatory region located in the first intron of the alpha-fetoprotein (AFP) gene. We show that the enhancer activity of the region depends on a 44 bp sequence centered on a CACCC motif. The sequence is the target of the two zinc fingers transcription factors BKLF and YY1. The introduction of a mutation destroying the CACCC box impairs the binding of BKLF but...

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Source

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Identifiers

PMID: 11000266
DOI: 10.1093/nar/28.19.3743
PMCID: PMC110759

Genes

AFP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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