A novel hepatocytic transcription factor that binds the alpha-fetoprotein promoter-linked coupling element.

doi:10.1128/mcb.14.10.6616-6626.1994

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Article

A novel hepatocytic transcription factor that binds the alpha-fetoprotein promoter-linked coupling element.

Molecular and cellular biology - 1 Oct 1994

Wen P, Locker J

Abstract excerpt

We recently characterized a promoter-linked coupling element (PCE) in the rat alpha-fetoprotein (AFP) gene required for strong transcriptional stimulation by distant enhancers (P. Wen, N. Crawford, and J. Locker, Nucleic Acids Res. 21:1911-1918, 1993). In this study, oligonucleotide gel retardation and competition experiments defined the PCE as a 12-bp binding site, TGTCCTTGAACA, an imperfect inverted repeat from...

Topics

Animals
Base Sequence
Binding, Competitive
Chloramphenicol O-Acetyltransferase
Cross-Linking Reagents
DNA Mutational Analysis
Humans
Liver
Molecular Sequence Data
Mutation
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Organ Specificity

Promoter Regions, Genetic

Protein Binding

Rats

Recombinant Fusion Proteins

Transcription Factors

Tumor Cells, Cultured

Source

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Identifiers

PMID: 7523856
DOI: 10.1128/mcb.14.10.6616-6626.1994
PMCID: PMC359191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7523856-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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