Article
Upstream stimulatory factors are involved in the P1 promoter directed transcription of the A beta H-J-J locus.
BMC molecular biology - 16 Dec 2008
Finotti Alessia, Treves Susan, Zorzato Francesco, Gambari Roberto, Feriotto Giordana
Abstract excerpt
BACKGROUND: Alternative splicing of the locus A beta H-J-J generates functionally distinct proteins: the enzyme aspartyl (asparaginyl) beta-hydroxylase (AAH), truncated homologs of AAH with a role in calcium homeostasis humbug and junctate and a structural protein of the sarcoplasmic reticulum membranes junctin. AAH and humbug are over expressed in a broad range of malignant neoplasms. We have previously reported...
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