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Infectious Entry Pathway Mediated by the Human Endogenous Retrovirus K Envelope Protein

21 Jan 2016

Abstract excerpt

UNLABELLED: Endogenous retroviruses (ERVs), the majority of which exist as degraded remnants of ancient viruses, comprise approximately 8% of the human genome. The youngest human ERVs (HERVs) belong to the HERV-K(HML-2) subgroup and were endogenized within the past 1 million years. The viral envelope protein (ENV) facilitates the earliest events of endogenization (cellular attachment and entry), and here, we...

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PMID: 26792739
DOI: 10.1128/jvi.03136-15

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