Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV-1 Rev interacts with HERV-K RcREs present in the human genome and promotes export of unspliced HERV-K proviral RNA

1 Dec 2019

Abstract excerpt

BACKGROUND: The HERV-K (HML-2) viruses are the youngest of the human endogenous retroviruses. They are present as several almost complete proviral copies and numerous fragments in the human genome. Many HERV-K proviruses express a regulatory protein Rec, which binds to an element present in HERV-K mRNAs called the RcRE. This interaction is necessary for the nucleo-cytoplasmic export and expression of HERV-K mRNAs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal and Genetic Variations
Share to vaccines and immunoinformatics approaches
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31842941
DOI: 10.1186/s12977-019-0505-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV-1 Rev interacts with HERV-K RcREs present in the human genome and promotes export of unspliced HERV-K proviral RNAPMID 31842941Read ↗

HIV-1 Rev interacts with HERV-K RcREs present in the human genome and promotes export of unspliced HERV-K proviral RNASemantic proximity Read ↗

Identification and characterization of functional and trans-dominant negative HERV-K (HML-2) Rec proteins encoded in the human genomeSemantic proximity Read ↗

Rec (Formerly Corf) Function Requires Interaction with a Complex, Folded RNA Structure within Its Responsive Element rather than Binding to a Discrete Specific Binding SiteSemantic proximity Read ↗

HERV-K(HML-2) rec and np9 transcripts not restricted to disease but present in many normal human tissuesSemantic proximity Read ↗

Comprehensive Characterization of the Human Endogenous Retrovirus HERV-K(HML-6) Group: Overview of Structure, Phylogeny, and Contribution to the Human GenomeSemantic proximity Read ↗

Targeting endogenous retrovirus gene transcription in human cancersSemantic proximity Read ↗

cORF and RcRE, the Rev/Rex and RRE/RxRE Homologues of the Human Endogenous Retrovirus Family HTDV/HERV-KSemantic proximity Read ↗

Human Endogenous Retrovirus K Rec forms a regulatory loop with MITF that opposes the progression of melanoma to an invasive stageSemantic proximity Read ↗

HERV-K HML-2 transcription in diverse cancers is related with cancer stem cell and epithelial-mesenchymal transition markersSemantic proximity Read ↗

Genomic Flexibility of Human Endogenous Retrovirus Type KSemantic proximity Read ↗

Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins.Semantic proximity Read ↗

Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.