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Sex-Specific and Non-Sex-Specific Quantitative Trait Loci Contribute to Normal Variation in Bone Mineral Density in Men

1 May 2005

Abstract excerpt

INTRODUCTION: A major determinant of osteoporotic fracture is peak bone mineral density (BMD). In women peak BMD is highly heritable and several quantitative trait loci (QTL) have been reported. There are few comparable data in men. This study in men aimed to establish the heritability of peak BMD, identify QTL contributing to normal variation in BMD, and determine which QTL might be sex specific. METHODS: BMD at...

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PMID: 15741260
DOI: 10.1210/jc.2004-2143

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