Article
Predicting response to chronic antihypertensive treatment with fosinopril: the role of angiotensin-converting enzyme gene polymorphism.
Cardiovascular drugs and therapy - 1 Aug 2000
Stavroulakis G A, Makris T K, Krespi P G, Hatzizacharias A N, Gialeraki A E, Anastasiadis G, Triposkiadis P, Kyriakidis M
Abstract excerpt
Insertion (I)/deletion (D) polymorphism of the ACE gene has been reported to be involved in various cardiovascular diseases. We investigated prospectively whether the response to the ACE inhibitor fosinopril varied according to the ACE genotype in previously untreated Greek hypertensive patients. After a 4-week observation period, fosinopril was administered at a dose of 20 mg daily and blood pressure was...
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