Article
The ACE-DD genotype is associated with endothelial dysfunction in postmenopausal women.
Menopause (New York, N.Y.) - 1 Jan 2000
Méthot Julie, Hamelin Bettina A, Arsenault Marie, Bogaty Peter, Plante Sylvain, Poirier Paul
Abstract excerpt
OBJECTIVE: To evaluate the effects of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D), the angiotensinogen M235T and the angiotensin II type 1 receptor A1166C polymorphisms, and hormone therapy used on endothelial function in postmenopausal women without manifestation of coronary artery disease. DESIGN: Sixty-four postmenopausal women (42 hormone therapy users and 22 hormone therapy nonusers)...
Topics
- Alleles
- Angiotensinogen
- Brachial Artery
- Endothelium, Vascular
- Female
- Gene Deletion
- Genotype
- Hormone Replacement Therapy
- Humans
- Middle Aged
- Peptidyl-Dipeptidase A
- Polymorphism, Genetic
- Postmenopause
- Receptor, Angiotensin, Type 1
- Renin-Angiotensin System
- Ultrasonography