Article
Vascular effects of quinapril completely depend on ACE insertion/deletion polymorphism.
Journal of the renin-angiotensin-aldosterone system : JRAAS - 1 Sept 2004
Voors Adriaan A, van Geel Peter P, Oosterga Margreeth, Buikema Hendrik, van Veldhuisen Dirk J, van Gilst Wiek H
Abstract excerpt
INTRODUCTION: The angiotensin-converting enzyme (ACE) DD-genotype is associated with increased plasma and myocardial ACE-activity. The influence of the ACE insertion/deletion (I/D) polymorphism on the effects of ACE-inhibition on vascular responses has not been previously described. MATERIALS AND METHODS: In the randomised, double-blind QUinapril On Vascular ACE and Determinants of Ischemia Study (QUO VADIS), 149...
Topics
- Angiotensin II
- Angiotensin-Converting Enzyme Inhibitors
- Coronary Artery Bypass
- DNA Transposable Elements
- Double-Blind Method
- Gene Deletion
- Genotype
- Humans
- Mammary Arteries
- Peptidyl-Dipeptidase A
- Polymorphism, Genetic
- Quinapril
- Tetrahydroisoquinolines