Article
Aberrant pH of melanosomes in pink-eyed dilution (p) mutant melanocytes.
The Journal of investigative dermatology - 1 Oct 2000
Puri N, Gardner J M, Brilliant M H
Abstract excerpt
In past studies, we cloned the mouse p gene and its human homolog P, which is associated with oculocutaneous albinism type 2. Both mouse and human genes are expressed in melanocytes and encode proteins predicted to have 12 membrane-spanning domains with structural homology to known ion transporters. We have also demonstrated that the p protein is localized to the melanosomal membrane and does not function as a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.