Article
Pigment dilution mutants from fish models with connection to lysosome-related organelles and vesicular traffic genes.
Zebrafish - 1 Dec 2008
Navarro Rosa E, Ramos-Balderas Jose L, Guerrero Isabel, Pelcastre Vladimir, Maldonado Ernesto
Abstract excerpt
An interesting question in developmental biology is why mutations in genes with functions essential for the majority of cells produce diseases affecting only specific tissues. For example, pigment dilution disorders are often the consequence of mutations in conserved vesicular traffic genes. In Hermansky-Pudlak, Griscelli, and Chediak-Higashi pigment dilution syndromes, vesicular traffic mutations affect several...
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