Article

The lysosomal chloride-proton exchanger CLC7 functions in melanosomes as a negative regulator of human pigmentation

2021-02-06

Abstract excerpt

Mutations in the Cl − /H + exchanger CLC7 and its subunit OSTM1 result in osteopetrosis, lysosomal disorders, and pigmentation defects in mice and humans. How CLC7/OSTM1 regulates pigmentation in skin and hair melanocytes remains unexplored. In human epidermal melanocytes, we found CLC7/OSTM1 localized to melanosomes, the organelles in which melanin is synthesized, where it negatively regulates melanin productio...

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Literature Corpus work: 76da0590-8e99-506d-8f48-8af2c777c763
DOI: 10.1101/2021.02.05.430016

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