Article
Subcellular distribution of tyrosinase and tyrosinase-related protein-1: implications for melanosomal biogenesis.
The Journal of investigative dermatology - 1 Jan 1993
Orlow S J, Boissy R E, Moran D J, Pifko-Hirst S
Abstract excerpt
Are tyrosinase, encoded at the albino locus, and tyrosinase-related protein-1 (TRP-1), encoded at the brown locus, similarly distributed in melanocytes? We determined the subcellular distribution of tyrosinase and TRP-1 using density fractionation of postnuclear supernatants from mouse melanoma c...
Topics
- Antigens, CD
- Fluorescent Antibody Technique
- Humans
- Lysosomal Membrane Proteins
- Melanocytes
- Melanoma
- Membrane Glycoproteins
- Microscopy, Immunoelectron
- Monophenol Monooxygenase
- Mutation
- Oxidoreductases
- Proteins
- Skin Pigmentation
- Subcellular Fractions
- Tumor Cells, Cultured