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Article

Subcellular distribution of tyrosinase and tyrosinase-related protein-1: implications for melanosomal biogenesis.

The Journal of investigative dermatology - 1 Jan 1993

Orlow S J, Boissy R E, Moran D J, Pifko-Hirst S

Abstract excerpt

Are tyrosinase, encoded at the albino locus, and tyrosinase-related protein-1 (TRP-1), encoded at the brown locus, similarly distributed in melanocytes? We determined the subcellular distribution of tyrosinase and TRP-1 using density fractionation of postnuclear supernatants from mouse melanoma cells of defined genotype followed by immunoblotting with specific antipeptide sera. In highly melanized cells, the...

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PMID: 8423398
DOI: 10.1111/1523-1747.ep12354138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Subcellular distribution of tyrosinase and tyrosinase-related protein-1: implications for melanosomal biogenesis.PMID 8423398Read ↗

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