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Article

Vacuolar-type H(+)-ATPase with the a3 isoform is the proton pump on premature melanosomes.

Cell and tissue research - 1 Jun 2008

Tabata Hiroyuki, Kawamura Nobuyuki, Sun-Wada Ge-Hong, Wada Yoh

Abstract excerpt

The melanosome, an organelle specialized for melanin synthesis, is one of the lysosome-related organelles. Its lumen is reported to be acidified by vacuolar-type H(+)-ATPase (V-ATPase). Mammalian V-ATPase exhibits structural diversity in its subunit isoforms; with regard to membrane intrinsic subunit a, four isoforms (a1-a4) have been found to be localized to distinct subcellular compartments. In this study, we...

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PMID: 18408955
DOI: 10.1007/s00441-008-0597-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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