Article
Normal tyrosine transport and abnormal tyrosinase routing in pink-eyed dilution melanocytes.
Experimental cell research - 10 Oct 1998
Potterf S B, Furumura M, Sviderskaya E V, Santis C, Bennett D C, Hearing V J
Abstract excerpt
The pink-eyed dilution phenotype in mice arises from mutations in the p gene; in humans, analogous mutations in the P gene result in oculocutaneous albinism type 2. Although the molecular mechanisms which underlie this phenotype remain obscure, it has been postulated that mutations in p result in...
Topics
- Albinism, Oculocutaneous
- Animals
- Biological Transport
- Carrier Proteins
- Cell Line
- Melanins
- Melanocytes
- Membrane Proteins
- Mice
- Mice, Inbred C57BL
- Monophenol Monooxygenase
- Mutation
- Phenotype
- Pigmentation
- Subcellular Fractions
- Tyrosine