Article
PML-RARA fusion transcripts in irradiated and normal hematopoietic cells.
Genes, chromosomes & cancer - 1 Nov 2000
Quina A S, Gameiro P, Sá da Costa M, Telhada M, Parreira L
Abstract excerpt
It is believed that two important factors in the genesis of reciprocal chromosomal translocations in malignant cells are the physical proximity of the involved regions and local structural features of the chromatin fiber that make them more susceptible to breakage and rearrangement. In this work we sought to investigate whether PML-RARA fusion transcripts, characteristic of acute promyelocytic leukemia (APL),...
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