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Article

Atypical mRNA fusions in <i>PML‐RARA</i> positive, <i>RARA‐PML</i> negative acute promyelocytic leukemia

12 Feb 2010

Abstract excerpt

Reciprocal RARA-PML transcripts are not detected in approximately 25% of patients with PML-RARA positive acute promyelocytic leukemia (APL), but the reasons for this are poorly understood. We studied 21 PML-RARA positive/RARA-PML negative cases by bubble PCR and multiplex long template PCR to identify the genomic breakpoints. Additional RT-PCR analysis was performed based on the DNA findings. Three cases were...

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PMID: 20155840
DOI: 10.1002/gcc.20757

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