Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.

doi:10.1002/j.1460-2075.1992.tb05185.x

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Article

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.

The EMBO journal - 1 Apr 1992

Pandolfi P P, Alcalay M, Fagioli M, Zangrilli D, Mencarelli A, Diverio D, Biondi A, Lo Coco F, Rambaldi A, Grignani F

Abstract excerpt

The acute promyelocytic leukaemia (APL) 15;17 translocation generates a PML/RAR alpha chimeric gene which is transcribed as a fusion PML/RAR alpha mRNA. Molecular studies on a large series of APLs revealed great heterogeneity of the PML/RAR alpha transcripts due to: (i) variable breaking of chromosome 15 within three PML breakpoint cluster regions (bcr1, bcr2 and bcr3), (ii) alternative splicings of the PML...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blotting, Southern
Bone Marrow
Carrier Proteins
Chimera
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 17
DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Genomic Library

Humans

Introns

Leukemia, Promyelocytic, Acute

Molecular Sequence Data

Multigene Family

Neoplasm Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1314166
DOI: 10.1002/j.1460-2075.1992.tb05185.x
PMCID: PMC556589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1314166-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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