Article
Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy.
Proceedings of the National Academy of Sciences of the United States of America - 28 May 2002
Gu Bai-Wei, Xiong Hui, Zhou Yan, Chen Bing, Wang Li, Dong Shuo, Yu Zhi-Yuan, Lu Ling-Feng, Zhong Ming, Yin Hai-Feng, Zhu Gen-Feng, Huang Wei, Ren Shuang-Xi, Gallagher Robert E, Waxman Samuel, Chen Guo-Qiang, Wang Zhu-Gang, Chen Zhu, Fu Gang, Chen Sai-Juan
Abstract excerpt
The physiologic actions of retinoic acids (RAs) are mediated through RA receptors (RARs) and retinoid X receptors (RXRs). The RAR(alpha) gene has drawn particular attention because it is the common target in all chromosomal translocations in acute promyelocytic leukemia (APL), a unique model in cancer research that responds to the effect of RA. In the great majority of patients with APL, RAR(alpha) is fused to...
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