Article

Uncovering the <em>PML::RARA </em>Fusion in Cytogenetically Cryptic and FISH-Negative Acute Promyelocytic Leukemia - A Case Report and Comprehensive Literature Review

2025-08-30

Abstract excerpt

The PML::RARA fusion resulting from t(15;17) is the genetic hallmark of acute promyelocytic leukemia (APL), typically detected by cytogenetics and/or fluorescence in situ hybridization (FISH) studies. Rarely, APL patients present with normal cytogenetics and FISH findings, complicating diagnosis and delaying life-saving therapy. We report a 23-year-old male with clinical, morphologic and immunophenotypic features...

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Literature Corpus work: 3cbf34f4-0db5-5b94-a48d-b46dfbdf3f63
DOI: 10.20944/preprints202508.2198.v1

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