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Article

PML nuclear body disruption impairs DNA double-strand break sensing and repair in APL

28 Jul 2016

Abstract excerpt

Proteins involved in DNA double-strand break (DSB) repair localize within the promyelocytic leukemia nuclear bodies (PML-NBs), whose disruption is at the root of the acute promyelocytic leukemia (APL) pathogenesis. All-trans-retinoic acid (RA) treatment induces PML-RARα degradation, restores PML-NB functions, and causes terminal cell differentiation of APL blasts. However, the precise role of the APL-associated...

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PMID: 27468685
DOI: 10.1038/cddis.2016.115

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