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Article

Lung tumours from non-smoking subjects: A p53-related genetic instability in a subset of cases.

International journal of molecular medicine - 1 Oct 1999

Pellegrini S, Bertacca G, Buttitta F, Bevilacqua G, Marchetti A

Abstract excerpt

Tumours developed in non-smoking patients represent about 10% of all lung neoplasms and show peculiar morphologic and genetic features. In a previous study, we found a constant association between p53 gene alterations and loss of heterozygosity (LOH) at the FHIT locus in a subset of non-smoking tumours (7 cases out of 35 analyzed), so we hypothesized that a genomic instability associated with p53 mutations could...

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Share to FHIT gene
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Source

Identifiers

PMID: 10493985
DOI: 10.3892/ijmm.4.4.419

Genes

FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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