Article
Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene.
Genome research - 1 Oct 2000
Nickerson D A, Taylor S L, Fullerton S M, Weiss K M, Clark A G, Stengård J H, Salomaa V, Boerwinkle E, Sing C F
Abstract excerpt
A common strategy for genotyping large samples begins with the characterization of human single nucleotide polymorphisms (SNPs) by sequencing candidate regions in a small sample for SNP discovery. This is usually followed by typing in a large sample those sites observed to vary in a smaller sample. We present results from a systematic investigation of variation at the human apolipoprotein E locus (APOE), as well...
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