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Article

The apolipoprotein E (APOE) gene appears functionally monomorphic in chimpanzees (Pan troglodytes).

PloS one - 1 Jan 2012

McIntosh Annick M, Bennett Calvin, Dickson Dara, Anestis Stephanie F, Watts David P, Webster Timothy H, Fontenot M Babette, Bradley Brenda J

Abstract excerpt

BACKGROUND: The human apolipoprotein E (APOE) gene is polymorphic, with three primary alleles (E2, E3, E4) that differ at two key non-synonymous sites. These alleles are functionally different in how they bind to lipoproteins, and this genetic variation is associated with phenotypic variation for several medical traits, including cholesterol levels, cardiovascular health, Alzheimer's disease risk, and longevity....

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Source

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Identifiers

PMID: 23112842
DOI: 10.1371/journal.pone.0047760
PMCID: PMC3480407

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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