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Article

Implications of <i>EPHB6</i> , <i>EFNB2</i> , and <i>EFNB3</i> expressions in human neuroblastoma

12 Sept 2000

Abstract excerpt

Neuroblastoma (NB) is a common pediatric tumor that exhibits a wide range of biological and clinical heterogeneity. EPH (erythropoietin-producing hepatoma amplified sequence) family receptor tyrosine kinases and ligand ephrins play pivotal roles in neural and cardiovascular development. High-level expression of transcripts encoding EPHB6 receptors (EPHB6) and its ligands ephrin-B2 and ephrin-B3 (EFNB2, EFNB3) is...

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PMID: 10984508
DOI: 10.1073/pnas.190123297

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