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Article

The <i>MYCN</i> Enigma: Significance of <i>MYCN</i> Expression in Neuroblastoma

1 Mar 2006

Abstract excerpt

MYCN amplification strongly predicts adverse outcome of neuroblastoma. However, the significance of MYCN expression in the clinical and biological behavior of neuroblastoma has been unclear. To address this question, we first examined the expression of MYCN in combination with TrkA (a favorable prognostic indicator of neuroblastoma) in 91 primary neuroblastoma by quantitative reverse transcription-PCR and...

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PMID: 16510605
DOI: 10.1158/0008-5472.can-05-0854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The <i>MYCN</i> Enigma: Significance of <i>MYCN</i> Expression in NeuroblastomaPMID 16510605Read ↗

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Combining TrkA Immunohistochemical-Score with Clinicopathologic Parameters in Neuroblastoma: An Influential Prognostic NomogramSemantic proximity Read ↗

Silencing of MYCN by RNA interference induces growth inhibition, apoptotic activity and cell differentiation in a neuroblastoma cell line with MYCN amplificationSemantic proximity Read ↗

Heterogeneity of <i>MYCN</i> amplification in neuroblastoma at diagnosis, treatment, relapse, and metastasisSemantic proximity Read ↗

Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children’s Oncology Group studySemantic proximity Read ↗

Next‐generation RNA sequencing reveals differential expression of MYCN target genes and suggests the mTOR pathway as a promising therapy target in <i>MYCN‐</i>amplified neuroblastomaSemantic proximity Read ↗

Identification of patient subgroups with markedly disparate rates of <i>MYCN</i> amplification in neuroblastoma: A report from the International Neuroblastoma Risk Group projectSemantic proximity Read ↗

Clinically Relevant Cytotoxic Immune Cell Signatures and Clonal Expansion of T-Cell Receptors in High-Risk MYCN -Not-Amplified Human NeuroblastomaSemantic proximity Read ↗

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