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Article

Kinome multigenic panel identified novel druggable EPHB4-V871I somatic variant in high-risk neuroblastoma.

Journal of cellular and molecular medicine - 1 Jun 2020

Andolfo Immacolata, Lasorsa Vito A, Manna Francesco, Rosato Barbara E, Formicola Daniela, Iolascon Achille, Capasso Mario

Abstract excerpt

Neuroblastoma (NB) is the most common extracranial neoplasm in children. The overall outcome for high-risk NB patients is still unacceptable, therefore, it is critical to deeply understand molecular mechanisms associated with NB, which in turn can be utilized for developing drugs towards the treatment of NB. Protein kinases (TKs) play an essential role in the regulation of cell survival and proliferation....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32336043
DOI: 10.1111/jcmm.15297
PMCID: PMC7294133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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