Article
Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water.
Mutation research - 14 Jun 2013
O'Brien Travis J, Ding Hao, Suh Mina, Thompson Chad M, Parsons Barbara L, Harris Mark A, Winkelman William A, Wolf Jeffrey C, Hixon J Gregory, Schwartz Arnold M, Myers Meagan B, Haws Laurie C, Proctor Deborah M
Abstract excerpt
Chronic exposure to high concentrations of hexavalent chromium [Cr(VI)] as sodium dichromate dihydrate (SDD) in drinking water induces duodenal tumors in mice, but the mode of action (MOA) for these tumors has been a subject of scientific debate. To evaluate the tumor-site-specific genotoxicity and cytotoxicity of SDD in the mouse small intestine, tissue pathology and cytogenetic damage were evaluated in duodenal...
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