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Article

eIF2A, an initiator tRNA carrier refractory to eIF2α kinases, functions synergistically with eIF5B.

Cellular and molecular life sciences : CMLS - 1 Dec 2018

Kim Eunah, Kim Joon Hyun, Seo Keunhee, Hong Ka Young, An Seon Woo A, Kwon Junyoung, Lee Seung-Jae V, Jang Sung Key

Abstract excerpt

The initiator tRNA (Met-tRNA i Met ) at the P site of the small ribosomal subunit plays an important role in the recognition of an mRNA start codon. In bacteria, the initiator tRNA carrier, IF2, facilitates the positioning of Met-tRNA i Met on the small ribosomal subunit. Eukarya contain the Met-tRNA i Met carrier, eIF2 (unrelated to IF2), whose carrier activity is inhibited under stress conditions by the...

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Identifiers

PMID: 30019215
DOI: 10.1007/s00018-018-2870-4
PMCID: PMC6208778

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