Article
The 60-residue C-terminal region of the single-stranded DNA binding protein of herpes simplex virus type 1 is required for cooperative DNA binding.
Journal of virology - 1 Oct 2000
Mapelli M, Mühleisen M, Persico G, van Der Zandt H, Tucker P A
Abstract excerpt
ICP8 is the major single-stranded DNA (ssDNA) binding protein of the herpes simplex virus type 1 and is required for the onset and maintenance of viral genomic replication. To identify regions responsible for the cooperative binding to ssDNA, several mutants of ICP8 have been characterized. Total reflection X-ray fluorescence experiments on the constructs confirmed the presence of one zinc atom per molecule....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.