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On the domains of T4 phage sliding clamp gp45: An intermolecular crosstalk governs structural stability and biological activity.

Biochimica et biophysica acta. General subjects - 1 Jan 2017

Singh Manika Indrajit, Ganesh Bylapudi, Jain Vikas

Abstract excerpt

BACKGROUND: DNA polymerase processivity factors are ubiquitously present in all living organisms. Notwithstanding their high significance, the molecular details of clamps pertaining to the factors contributing to their stability are presently lacking. The bacteriophage T4 sliding clamp gp45 forms a homotrimer that besides being involved in DNA replication, moonlights as a transcription factor. Here we have...

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PMID: 27554844
DOI: 10.1016/j.bbagen.2016.08.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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