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Article

BRCA1 associates with human papillomavirus type 18 E2 and stimulates E2-dependent transcription.

Biochemical and biophysical research communications - 13 Jun 2003

Kim Jiyun, Lee Daeyoup, Gwan Hwang Sun, Hwang Eun-Seong, Choe Joonho

Abstract excerpt

BRCA1 is a breast and ovarian cancer-related tumor suppressor and has a role in transcriptional activation. We show here that BRCA1 enhances human papillomavirus type 18 (HPV-18) E2-dependent transcription in vivo. Using biochemical approaches, we discovered that BRCA1 interacts with the carboxyl-terminus of HPV-18 E2 protein in vivo and in vitro. Point mutations in the C-terminus make BRCA1 defective in...

Read the complete abstract on PubMed

Topics

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Share to Binding Sites
Share to BRCA1 Protein
Share to Oncogene Proteins, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to Protein Structure, Tertiary

Share to Trans-Activators

Share to Transcriptional Activation

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 12767931
DOI: 10.1016/s0006-291x(03)00880-5

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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