Article
Structure and expression of variant BRCA2a lacking the transactivation domain.
Oncology reports - 1 Jan 2000
Zou J P, Hirose Y, Siddique H, Rao V N, Reddy E S
Abstract excerpt
BRCA1 and BRCA2 are tumor suppressor genes shown to be involved in 90% of familial breast cancers and also known to be involved in ovarian and prostate cancers. Both BRCA1 and BRCA2 gene products are regulated in a cell cycle-dependent manner and have potential transactivation function. Here, we show that BRCA2 undergoes differential splicing giving rise to a novel variant protein BRCA2a, lacking putative...
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