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Article

BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2003

Shin Sook, Verma Inder M

Abstract excerpt

Germ-line mutations of the BRCA2 tumor suppressor gene greatly increase the risk of developing breast and ovarian cancers. Here, we show that wild-type BRCA2, but not a tumor-specific truncated mutant BRCA2, synergizes with the nuclear receptor coactivator p160 GRIP1 to enhance transcriptional activation by androgen receptor (AR). BRCA2 not only associates with AR and GRIP1 but also cooperates with both the...

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Share to Acetyltransferases
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Breast Neoplasms, Male

Share to Genes, BRCA2

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Source

Open in PubMed Open full text

Identifiers

PMID: 12756300
DOI: 10.1073/pnas.1132020100
PMCID: PMC165853

Genes

BRCA2
GRIP1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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